CHS Vascanox HP

The Effects

The physiological importance of nitric oxide was established by Nobel-prize winning research.

The physiological importance of nitric oxide was established in the 1990s and has since been confirmed by scientific studies and clinical experience.

In an open label published study, a single dose of Vascanox HP increased salivary nitric oxide levels for up to 24 hours.*†

Optimal nitric oxide levels have been shown to:

• Support a healthy cardiovascular system*
• Support and maintain blood pressure in the normal range*
• Support healthy circulation*

Vascanox HP is powered by Calroy’s proprietary blend, Noxa24®, to support the natural production, storage, and release of nitric oxide.* The formula targets nitric oxide metabolism, using multiple pathways.

†As measured by saliva NO test 

The Science

Nitric oxide is a messenger molecule that is produced in the body through both nitric oxide synthase (NOS) pathway and nitrate-nitrite-nitric oxide pathway. Vascanox HP supports the entire biotransformation cycle for nitric oxide, including both pathways.*

Nitric Oxide Synthase Pathway

Nitric oxide synthases are a group of 3 enzymes catalyzing production of nitric oxide in the body. Endothelial NOS (eNOS) is primarily responsible for the generation of nitric oxide in the vascular endothelium. The mechanical force of blood flow triggers a response in the endothelial glycocalyx, which in turn signals the endothelium to generate nitric oxide.

Nitrate -> Nitrite -> Nitric Oxide Pathway

This pathway starts when inorganic nitrate, such as dietary nitrate in green leafy vegetables is ingested and absorbed into the circulation. Circulating nitrate is transported into the saliva gland and concentrated in the saliva. If secreted in the mouth, nitrate in the saliva is reduced to nitrite by nitrate reducing bacteria. Once swallowed, part of the nitrite is chemically reduced to nitric oxide in the stomach and the rest can be reduced to nitric oxide by several different enzymes after being absorbed.

Vascanox HP contains a carefully curated selection of synergistic compounds derived from fruits and vegetables. In addition to potassium nitrate, a precursor for nitric oxide, a blend with polyphenols and antioxidant activities supports the entire biotransformation process for nitric oxide.

This dietary supplement is assembled using a Total Quality System, which includes strict compliance with cGMP’s current good manufacturing practices as defined by the United States Food and Drug Administration.

Batch and test records are maintained throughout the manufacturing process to ensure the guaranteed quality of the final product.